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郭欣副研究员简历
2017-09-29 15:35   作者:

基本信息

姓名:

郭欣

性别:

出生日期

1983.04

http://202.194.15.157:8080/_vsl/7ED53DE901168418CBF5987727CF9FAC/FF307D0B/9514

工作单位

龙虎国际娱乐营养与食品卫生学系

职称:

副研究员

Email

xguo@sdu.edu.cn

电话:

0531-88382135

地址:

济南市文化西路44号山东大学趵突泉校区

个人空间

 

 

⟡  个人简介

 

郭欣,女,美国德克萨斯州A&M大学(TEXAS   A&M UNIVERSITY)营养学博士,现为龙虎国际娱乐副研究员。长期从事代谢,慢性炎症,肥胖病,糖尿病等代谢疾病方面的工作研究。近五年在CirculationJournal of Biological     Chemistry JBC),PLoS ONEArteriosclerosis Thrombosis and Vascular BiologyATVB),Journal of Nutritional BiochemistryScientific Report等杂志上正式发表SCI论文12篇,其中第一作者4篇、第三作者4篇,每篇论文的影响因子在3-17之间;同时作为Scientific ReportsPLOS OneJournal of Cellular and Molecular     MedicineJournal of Nutrition & Food   SciencesJournal of Cell Science & Therapy 五个期刊的审稿人。另外于20137月获美国注册营养师执照、201310月获德克萨斯州注册营养师执照。

⟡  教育经历

 

20046月,江西师范大学,生物工程,学士学位。

20076月,中国科学技术大学,生物化学与分子生物学,硕士学位。

20135月,美国德克萨斯州农工大学(Texas   A&M University),营养学,博士学位。

⟡  工作经历

20137-20163月,美国德克萨斯州农工大学(Texas A&M   University)农学院营养与食品科学系,博士后研究助理。

20163-20178月,美国贝勒医学院儿童营养研究中心,助理研究员。

20179月至今,龙虎国际娱乐营养与食品卫生学系,副研究员。

⟡  学术任职

美国营养和饮食学会会员(Academy of Nutrition and Dietetics)

⟡  研究领域

肥胖症,糖尿病,心血管疾病等代谢疾病

⟡  在研项目

山东大学基本科研业务费项目2017TB0028,     2017.09-2019.12, 肥胖症中生物节律失调与脂肪组织炎症反应的关系, 15万元

⟡  主要发表论文 [20篇以内]

1.             Guo,   X., Shu, C., Zheng, J., Li, H.,   Pei, Y., Woo, S., Xu, H., Botchlett, R., Qi,   T., Guo, T., Zhao, J.,   Cai, Y., Hu, X., Zhao, Y., Huo, Y., Li, P., Wu, C.   Cyclic GMP-AMP   Ameliorates Diet-induced Metabolic Dysregulation and Regulates     Proinflammatory Responses Distinctly from STING Activation.  Scientific     Report. 2017, 7(1): 6355.

2.             Mo,   Q., Salley, J., Roshan, T.,   Baer, L., May, F., Jaehning, E., Lehing, A., Guo,   X., Tong, Q.,   Nuotio-Antar, A., Shamsi, F., Tseng, Y., Stanford, K., Chen, M.     Identification and characterization of a supraclavicular brown adipose tissue     in mice. Journal of Clinical Investigation Insight. 2017 June 2nd.

3.             Botchlett,   R., Woo, S., Liu, M.,   Pei, Y., Guo, X., Li, H., Wu, C. Nutritional approaches   for managing   obesity-associated metabolic diseases. Journal of Endocrinology.   2017,   233 (3) :R145.

4.             Botchlett,   R., Li, H., Guo, X., Qi,   T., Zhao, J., Zheng, J., Woo, S., Pei, Y., Liu, M.,   Hu, X., Chen,   G.,  Guo, T., Li, Q., Xiao, X., Huo, Y., and Wu, C.   Glucose and   Palmitate Differentially Regulate PFKFB3/iPFK2 and Inflammatory     Responses in Mouse Intestinal Epithelial Cells. Scientific Report. 2016, 6     :28963.

5.             Guo,   T., Woo, S., Guo, X., Li, H.,   Zheng, J., Botchlett, R., Liu, M., Pei, Y., Xu,   H., Cai, Y., Li. X.,   Li, Q., Xiao, X., Huo, Y., and Wu, C. Berberine   Ameliorates Hepatic   Steatosis and Suppresses Liver and Adipose Tissue   Inflammation in Mice   with Diet-induced Obesity. Scientific Report, 2016, Mar   3;6:22612.

6.             Xu,   H., Li, H., Woo, S., Kim, S.,   Shende, V. R., Neuendorff, N., Guo, X., Guo,   T., Qi, T., Pei, Y.,   Zhao, Y., Hu, X., Zhao, J., Chen, L., Chen, L., Ji, J.,   Alaniz, R.C.,   Earnest, D.J., Wu, C. Myeloid cell-specific disruption of   Period 1 and   Period 2 exacerbates diet-induced inflammation and insulin   resistance.   J Biol Chem, 2014; 289 (23): 16374-16388.

7.             Xu,   Y., An, X., Guo, X., Habtetsion,   T., Wang, Y., Xu, X., Kandala, S., Li, Q.,   Li, H., Zhang, C.,   Caldwell, R., Fulton, D., Su, Y., Hoda, M. N., Zhou, G.,   Wu, C., Huo,   Y. Endothelial PFKFB3 plays a critical role in angiogenesis.   ATVB,   2014; 34 (6): 1231-1239.

8.             Woo,   S., Xu, H., Li, H., Zhao, Y.,   Hu, X., Zhao, J., Guo, X., Guo, T., Botchlett,   R., Qi, T., Huo, Y.,   Wu, C. Metformin ameliorates hepatic steatosis and   inflammation   without altering adipose phenotype in Diet-Induced Obesity. PLoS   ONE,   2014; 9 (3), e91111.

9.             Chen,   Y., Mu, P., He, S., Tang, X.,   Guo, X., Li, H., Xu, H., Woo, S., Qian, X.,   Zeng, L., Wu C. Gly482Ser   mutation impairs the effects of peroxisome   proliferator–activated   receptor γ coactivator-1α on decreasing fat deposition   and stimulating   phosphoenolpyruvate carboxykinase expression in hepatocytes.   Nutrition   Research. 2013; 33 (4): 332-339.

10.       Li, H., Guo, X.   (co-first author, equal   contribution), Xu, H., Woo, S., Halim V., Morgan C.,   Wu, C. A role for   inducible 6-phosphofructo-2-kinase in the control of   neuronal   glycolysis J Nutr Biochem. 2013; 24 (6): 1153-1158.

11.       Guo, X., Li, H., Xu,   H., Halim, V., Thomas,   L.N., Woo, S., Huo, Y., Chen, Y. U., Sturino, J.M.,   and Wu, C.   Disruption of inducible 6-phosphofructo-2-kinase impairs the     suppressive effect of PPARγ activation on diet-induced intestine inflammatory     response. J Nutr Biochem, 2013; 24 (5): 770-775.

12.       Guo, X., Li, H., Xu,   H., Woo, S., Dong, H., Lu,   F., Lange, A.J., Wu, C. Glycolysis in the control   of blood glucose   homeostasis (Invited Review). Acta Pharmaceutica Sincia,   2012;   2:358-367.

13.       Guo X., Li H., Xu H.,   Halim V., Zhang W., Wang   H., Ong K.T., Woo S.L., Walzem R.L., Mashek D.G.,   Dong H., Lu F., Wei   L., Huo Y, and Wu C. Palmitoleate Induces Hepatic   Steatosis but   Suppresses Liver Inflammatory Response in Mice. PLoS ONE, 2012;     7:e39286. PMCID: PMC3387145.

14.       Huo, Y., Guo, X.   (co-first author, equal   contribution), Li, H., Xu, H., Halim, V., Zhang, W.,   Wang, H., Fan,   Y., Ong, K.T., Woo, S., Chapkin, R.S, Mashek,D.G., Chen, Y.,   Dong, H.,   Lu, F., Wei, L., Wu. C. Targeted overexpression of inducible     6-Phosphofructo-2-kinase in adipose tissue increases fat deposition but     protects against diet-induced insulin resistance and inflammatory   response. J   Biol Chem, 2012; 287(25): 21492-21500.

15.       Zhuang, G.., Meng, C.   (co-first author, equal   contribution), Guo, X., Xu, H., Wang, G., Li, H., and   Wu, C., Zhou,   B.  A Novel Regulator of Macrophage Activation miR-223 in   Obesity-Associated   Adipose Tissue Inflammation. Circulation, 2012; 125(23):   2892–2903.

16.       Guo, X., Huo, Y., Xu,   K., Li, H., Zhang, W.,   Wang, H., Zhang, J., Lange, A.J., Chen, Y.E., and Wu,   C. Involvement   of inducible 6-phosphofructo-2-kinase in the anti-diabetic   effect of   rosiglitazone in mice. J Biol Chem, 2010; 285: 23711-23720.

17.       Huo, Y., Guo, X., Li,   H., Wang, H., Zhang, W.,   Wang, Y., Zhou, H., Gao, Z., Telang, S., Chesney,   J., Chen, Y.E., Ye,   J., Chapkin, R.S., and Wu, C. Disruption of inducible     6-phosphofructo-2-kinase ameliorates diet-induced adiposity but exacerbates     systemic insulin resistance and adipose tissue inflammatory response.   J Biol   Chem, 2010; 285: 3713-3721.

18.         Chen,   Y.P., Shen, Y.Y., Guo, X.   (co-first author, equal contribution), Zhang, C.S.,   Yang, W.J., Ma,   M.L., Liu, S., Zhang, M.B., and Wen, L.P. Transdermal protein   delivery   by a coadministered peptide identified via phage display. Nature     Biotechnology, 2006; 455-460.

⟡  已获奖项

1. Outstanding   Graduate Award in Nutrition, Texas A&M   University, 2013

2. NFSC Award   in Excellence for Graduate Research   Assistant, Texas A&M   University, 2012

学术活动(近五年)

1.      郭欣,Regulation   of Gene Activation May   Become a Potential Strategy to Prevent and   Treat Nutrition-related Diseases,东湖论坛,   2016. 武汉,中国

2.      Guo,   X., Guo, T., Li, H., Pei, Y., Xu, H., Qi, Ting., Hu, X., Zhao,   Y., Zhao, J.,   Wu, C. Temporal effects pf Peroxisome   Proliferator-activated Receptor γ   (PPARγ) activation on macrophage inflammatory   responses. Experimental   Biology, 2014. San Diego, CA

 

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